NO-IMPARTING MATERIAL FOR TREATING ANAL DISEASE AND TREATMENT BY THE SAME

Japanese Patent JP3866906

B2

PROBLEM TO BE SOLVED: To obtain a pharmaceutical composition capable of treating anal diseases and reducing the pain accompanying to the anal diseases on its local administration at the anal zone or its vicinity not including anal canal by incorporating a carrier and an organic NO-imparting material.
SOLUTION: This pharmacological composition capable of treating anal diseases and reducing the pain accompanying to the anal diseases on its local administration at the anal zone or its vicinity of a subject having the anal diseases not including anal canal is obtained by containing (A) a carrier, (B) an organic NO-imparting material (e.g.; nitroglycerol) and, as necessary, (C) a corticosteroid and/or a local anesthesia. The composition is effective for treatment of the anal diseases, especially anal fissure, anal ulcer, hemorrhoids, levator spasm, or the like. In many patients, the composition can be used for treatments without any marantic adverse effect.

Stephen Earl. Jorphin

JP2000171337A

January 10, 2007

April 10, 1995

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Cerezi Pharmaceuticals, Inc.

A61K9/02; A61K31/21; A61K9/06; A61K31/34; A61K31/47; A61K31/56; A61K33/00; A61K45/00; A61K45/08; A61P1/00; A61P1/04; A61P3/00; A61P9/14; A61P17/00; A61P17/02; A61P25/02; A61P25/04; A61P29/00; A61P43/00; (IPC1-7): A61K45/08; A61P17/02; //A61K9/06; A61K31/21

Gut,1993年 4月,Vol.34,S25
Gastroenterology ,1993年 4月,Vol.104, No.4,A544
Br. J. Surg.,1986年,Vol.73,p.443-445
Pharmacological Reviews,1991年,Vol.43, No.3,p.351-353

Hidesaku Yamamoto

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