Title:
医薬としての非酸性シクロペンタンヘプタン酸,2-シクロアルキルまたはアリールアルキル誘導体
Document Type and Number:
Japanese Patent JP3681068
Kind Code:
B2
Abstract:
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, either or thioether groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) derivatives of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.
Inventors:
Woodward, David F
Andrews, Stephen W
Burke, Robert M
Gerst, Michael Yee
Andrews, Stephen W
Burke, Robert M
Gerst, Michael Yee
Application Number:
JP50815594A
Publication Date:
August 10, 2005
Filing Date:
September 09, 1993
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
A61K31/045; A61K31/075; A61K31/13; A61K31/16; A61K31/275; A61K31/381; A61K31/557; A61K31/5575; A61K31/5585; A61K31/655; A61P1/00; A61P1/16; A61P9/00; A61P11/00; A61P13/02; A61P15/00; A61P27/02; A61P27/06; A61P27/14; A61P37/08; A61P43/00; C07C35/21; C07C35/50; C07C69/732; C07C69/734; C07C205/17; C07C215/42; C07C235/34; C07C247/10; C07C255/36; C07C405/00; (IPC1-7): C07C235/34; A61K31/16; A61K31/5575; A61P27/06; C07C405/00
Domestic Patent References:
| JP50069045A | ||||
| JP59190964A | ||||
| JP56167665A | ||||
| JP53121760A | ||||
| JP51125042A | ||||
| JP53124243A | ||||
| JP56011699B1 |
Foreign References:
| WO1992008465A1 | ||||
| US4128577 |
Other References:
Prostaglandins, 1979年,17(3), p.441-449
Attorney, Agent or Firm:
Aoyama Aoi
Yasuo Shibata
Yasuo Shibata