Title:
診断および治療に有用な非共有結合的バイオコンジュゲート
Document Type and Number:
Japanese Patent JP4560209
Kind Code:
B2
Abstract:
A composition comprising non-covalent carrier-hapten bioconjugates having the formula HM-----CM wherein HM is a hapten molecule whose molecular weight is generally, but not always, less than 1000 Daltons and is capable of performing specific functions; CM is a carrier molecule, whose molecular weight is generally, but not always, more than 1000 Daltons and is capable of transporting the hapten to a specific site; and the dashed line is a non-covalent bond between the carrier molecule and the hapten molecule. The bioconjugates are formed from cyanine and carrier molecules such as methylated serum albumin, polyarginine, polyaspartic acid, polyglutamic acid, cyclodextrin, and inulin. The bioconjugates are useful in diagnostic and therapeutic medical procedures because they are stable in vitro before being used and stable in vivo during and after use.
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Inventors:
Ragaban Rajago Paran
Joseph E. Bugaju
Richard B. Doshaw
Samuel I Achirev
Joseph E. Bugaju
Richard B. Doshaw
Samuel I Achirev
Application Number:
JP2000542054A
Publication Date:
October 13, 2010
Filing Date:
March 31, 1999
Export Citation:
Assignee:
Mallinckrodt INC.
International Classes:
A61K49/00; G01N33/483; A61K41/00; A61K45/08; A61P31/00; A61P35/00; G01N21/78; G01N33/533
Domestic Patent References:
| JP5508015A | ||||
| JP62103572A |
Foreign References:
| DE4445065A1 | ||||
| US5110794 |
Other References:
SAUDA, K. et al.,Analytical Chemistry,1986年,Vol.58,pp.2649-2653
DAVIS, D. et al.,Research Communications in Chemical Pathology and Pharmacology,1980年,Vol.27, No.2,pp.373-388
BAPTISTA, M. et al.,Chemical Communications,1997年,pp.1791-1792
DAVIS, D. et al.,Research Communications in Chemical Pathology and Pharmacology,1980年,Vol.27, No.2,pp.373-388
BAPTISTA, M. et al.,Chemical Communications,1997年,pp.1791-1792
Attorney, Agent or Firm:
Takeshi Oshio