Title:
放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術
Document Type and Number:
Japanese Patent JP4530665
Kind Code:
B2
Abstract:
The invention provides lipophilic salts, particularly, lipophilic salts comprising a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. In certain embodiments, the cation is labeled with one or more radioisotopes. The lipophilic salts of the invention exhibit an affinity for dysfunctional mitochondria, and are useful for the imaging of cardiovascular diseases and disorders. The invention also provides pharmaceutical compositions and methods of using the lipophilic salts.
Inventors:
Egal Madal
Heiden tea lavato
Robert Danals
Ersula A. Scheffel
James Jay Frost
Heiden tea lavato
Robert Danals
Ersula A. Scheffel
James Jay Frost
Application Number:
JP2003565315A
Publication Date:
August 25, 2010
Filing Date:
February 06, 2003
Export Citation:
Assignee:
Johns Hopkins University
International Classes:
A61K49/00; A61K51/00; A61K51/04; C07C211/63; A61P35/00; C07B59/00; C07C211/64; C07F9/54
Domestic Patent References:
| JP59139326A |
Foreign References:
| WO2001082864A1 |
Other References:
Madar, Igal; Anderson, James H.; Szabo, Zsolt; Scheffel, Ursula; Kao, Pan-Fu; Ravert, Hayden T.; Dannals, Robert F.,Enhanced uptake of [11C]TPMP in canine brain tumor: a PET study,Journal of Nuclear Medicine,1999年,40(7),1180-1185
Srivastava, P. C.; Knapp, F. F., Jr.; Callahan, A. P.; Goldstein, B. M.,Myocardial imaging agents: synthesis, characterization and evaluation of [(Z)- and (Z,E)-(1-[82Br]bromo-1-penten-5-yl)]triphenylphosphonium cations,Journal of Labelled Compounds and Radiopharmaceuticals ,1990年,28(10),1161-9
Srivastava, P. C.; Hay, H. G.; Knapp, F. F., Jr.,Effects of alkyl and aryl substitution on the myocardial specificity of radioiodinated phosphonium, arsonium, and ammonium cations,Journal of Medicinal Chemistry,1985年,28(7),901-4
Srivastava, P. C.; Knapp, F. F., Jr.,[(E)-1-[123I]Iodo-1-penten-5-yl]triphenylphosphonium iodide: convenient preparation of a potentially useful myocardial perfusion agent,Journal of Medicinal Chemistry,1984年,27(8),978-81
Wilson, Alan A.; Dannals, Robert F.; Ravert, Hayden T.; Burns, H. Donald; Wagner, Henry N., Jr.,Iodine-125- and iodine-123-labeled iodobenzyl bromide, a useful alkylating agent for radiolabeling biologically important molecules,Journal of Labelled Compounds and Radiopharmaceuticals ,1986年,23(1),83-93
Hoernfeldt, Katarina; Laangstroem, Bengt,Journal of Labelled Compounds and Radiopharmaceuticals ,Journal of Labelled Compounds and Radiopharmaceuticals ,1994年,34(8),707-15
Oegren, M.; Hoernfeldt, K.; Fasth, K. J.; Laengstroem, B.,11C-labeled polymer-bound Wittig reagents in the synthesis of 11C-labeled aromatic alkenes,Applied Radiation and Isotopes,1995年,46(8),771-5
Chemical Abstracts,vol.92,abs.no.58514
Srivastava, P. C.; Knapp, F. F., Jr.; Callahan, A. P.; Goldstein, B. M.,Myocardial imaging agents: synthesis, characterization and evaluation of [(Z)- and (Z,E)-(1-[82Br]bromo-1-penten-5-yl)]triphenylphosphonium cations,Journal of Labelled Compounds and Radiopharmaceuticals ,1990年,28(10),1161-9
Srivastava, P. C.; Hay, H. G.; Knapp, F. F., Jr.,Effects of alkyl and aryl substitution on the myocardial specificity of radioiodinated phosphonium, arsonium, and ammonium cations,Journal of Medicinal Chemistry,1985年,28(7),901-4
Srivastava, P. C.; Knapp, F. F., Jr.,[(E)-1-[123I]Iodo-1-penten-5-yl]triphenylphosphonium iodide: convenient preparation of a potentially useful myocardial perfusion agent,Journal of Medicinal Chemistry,1984年,27(8),978-81
Wilson, Alan A.; Dannals, Robert F.; Ravert, Hayden T.; Burns, H. Donald; Wagner, Henry N., Jr.,Iodine-125- and iodine-123-labeled iodobenzyl bromide, a useful alkylating agent for radiolabeling biologically important molecules,Journal of Labelled Compounds and Radiopharmaceuticals ,1986年,23(1),83-93
Hoernfeldt, Katarina; Laangstroem, Bengt,Journal of Labelled Compounds and Radiopharmaceuticals ,Journal of Labelled Compounds and Radiopharmaceuticals ,1994年,34(8),707-15
Oegren, M.; Hoernfeldt, K.; Fasth, K. J.; Laengstroem, B.,11C-labeled polymer-bound Wittig reagents in the synthesis of 11C-labeled aromatic alkenes,Applied Radiation and Isotopes,1995年,46(8),771-5
Chemical Abstracts,vol.92,abs.no.58514
Attorney, Agent or Firm:
Norio Saeki