To judge non invasively selective neuronal necrosis not involving cerebral infraction or cerebral hemorrhage in a mammal by detecting a specific MRI image showing the high signal area by a T1 highlighted image and the low signal area by a T2 highlighted image in a nuclear magnetic resonance image(MRI).
In a 15-minute MCAO(temporal middle cerebral artery obstruction of a rat) model, the result of histological considerations of the brain 14 days later shows that a selective neuronal necrosis and gliosis were recognized for a region where a signal change (high signal area in the T1 highlighted image and low signal area in the T2 highlighted image) was observed. However, cerebral infarction and cerebral hemorrhage were not observed. In a 60-minute MCAO model, a change in the low signal area in the T1 highlighted image and the high signal area in the T2 highlighted image occurred in the striatum and the cerebral cortex and the change corresponded histologically to cerebral infarction. A signal change in an MRI image recognized in the cerebral tissue after ischemic invasion can be an indicator suggestive of an existence of selective neuronal necrosis not involving cerebral infraction or cerebral hemorrhage.
TAOKA TOSHIAKI
MATSUO YOSHIYUKI
TAOKA TOSHIAKI
SHIONOGI & CO