Title:
非ヌクレオシド逆転写酵素インヒビター
Document Type and Number:
Japanese Patent JP2005538155
Kind Code:
A
Abstract:
A compound of the formula (Y): where; R1 is O, S; R2 is a nitrogen-containing heterocycle; R3 is H, C1-C3 alkyl; X is -(CR8R8')n-D-(CR8R8')m-; D is a bond, -NR9-, -O-, -S-, -S(-O)- or -S(-O)2-; n and m are independently 0, 1 or 2, R8 and R8' are independently H, C1-C3 alkyl, haloC1-C3alkyl, hydroxy, or R8 and R8' together with their adjacent C atom is -C(-O)-; R9 is independently H, C1-C3 alkyl; E is CH2-, -CHOH-, -C(-O)-, -NR9-, -O-, -S-, -S(-O)2-; n and m are independently 0, 1 or 2; p and q are independently 0, 1 or 2, where p+q<=2; R10 is an optionally substituted carbocycle or heterocycle; R11 is independently H, C1-C3 alkyl, halo substituted C1-C3alkyl, hydroxy; have utility as HIV antivirals.
Inventors:
Dmitry Antonov
Christian Sund
Stefan Lindström
Christel Sarbarii
Christian Sund
Stefan Lindström
Christel Sarbarii
Application Number:
JP2004533489A
Publication Date:
December 15, 2005
Filing Date:
September 05, 2003
Export Citation:
Assignee:
MEDIVIR AKTIEBOLAG
International Classes:
C07D213/84; A61K31/425; A61K31/426; A61K31/44; A61K31/4433; A61K31/5377; A61K45/00; A61P31/18; C07D213/65; C07D213/73; C07D213/75; C07D307/93; C07D311/94; C07D333/78; C07D335/06; C07D405/12; C07D405/14; C07D409/12; (IPC1-7): C07D213/84; A61K31/44; A61K31/4433; A61K31/5377; A61K45/00; A61P31/18; C07D405/12; C07D405/14; C07D409/12
Attorney, Agent or Firm:
Kyousei Tamura
Toshio Ueda
Nagatoshi Shinagawa
Toshio Ueda
Nagatoshi Shinagawa