非ペプチド性重合体リンカー化合物、そのリンカー化合物を含む結合体、及びそれらの製造方法

Japanese Patent JP7121024

B2

One aspect of the present invention provides a compound in which a functional group capable of binding to a globulin Fc region or a physiologically active polypeptide is introduced at one end of a non-peptidic polymer and a functional group capable of a click reaction is introduced at the other end; a polypeptide conjugate in which a physiologically active polypeptide binds to one end of the compound; a physiologically active polypeptide conjugate in which a physiologically active polypeptide and an immunoglobulin Fc region bind to both ends thereof by using the compound as a linker; and methods for preparing the same compound, polypeptide conjugate, and physiologically active polypeptide conjugate.

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Su Young Park
Te Jin Kim
Sun Yub Jun
Yong Kyu Jun
Hyun Sik Yoon

JP2019542628A

August 17, 2022

February 07, 2018

Click for automatic bibliography generation  

Hanmi Pharmaceuticals Company Limited

C08G65/333; A61K38/26; A61K39/395; A61K45/00; A61K47/60; A61K47/68; C07D209/52; C07D225/08; C07D413/06

JP2017014371A
JP2016529227A
JP2018062655A

WO2016054315A1

"Site-Specific Conjugation of ScFvs Antibodies to Nanoparticles by Bioorthogonal Strain-Promoted Alkyne-Nitrone Cycloaddition",Angewandte Chemie International Edition,Vol.51,2012年,p.496-499

Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe

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