Title:
NONAQUEOUS SKIN EXTERNAL COMPOSITION AND MANUFACTURING METHOD OF THE SAME
Document Type and Number:
Japanese Patent JP2019069912
Kind Code:
A
Abstract:
To provide a nonaqueous skin external composition in which strongly hydrophobic and amphiphilic solid active ingredient is solubilized into oil phase.SOLUTION: A nonaqueous skin external composition is given in which strongly hydrophobic and amphiphilic solid active ingredient-surfactant complex is melted or distributed in oil phase as particles of size: 2-200 nm. A manufacturing method of the nonaqueous skin external composition solubilizing strongly hydrophobic and amphiphilic solid active ingredient in the oil phase comprises the steps of: adding the strongly hydrophobic and amphiphilic solid active ingredient to aqueous phase to obtain aqueous phase mixture; adding surfactant to oil phase to obtain oil phase mixture; mixing the aqueous phase mixture and the oil phase mixture to obtain water-in-oil type emulsion; lyophilizing the obtained water-in-oil type emulsion to obtain the strongly hydrophobic and amphiphilic solid active ingredient-surfactant complex; and melting or distributing the obtained strongly hydrophobic and amphiphilic solid active ingredient-surfactant complex in the oil phase to melt or distribute the strongly hydrophobic and amphiphilic solid active ingredient-surfactant complex in the oil phase as particles of size: 2-200 nm.SELECTED DRAWING: None
Inventors:
MIYAMOTO MASAYOSHI
ODA YOSHIJI
ODA YOSHIJI
Application Number:
JP2017195931A
Publication Date:
May 09, 2019
Filing Date:
October 06, 2017
Export Citation:
Assignee:
CHANEL KESHOHIN GIJUTSU KAIHATSU KENKYUSHO KK
International Classes:
A61K8/44; A61K8/37; A61K8/55; A61K8/67; A61K8/86; A61K9/08; A61K9/10; A61K31/198; A61K31/225; A61K31/375; A61K31/661; A61K47/14; A61K47/34; A61K47/44; A61P17/00; A61Q19/00
Domestic Patent References:
| JP2017165699A | 2017-09-21 | |||
| JP2007269682A | 2007-10-18 | |||
| JP2007254389A | 2007-10-04 | |||
| JPH10509735A | 1998-09-22 | |||
| JP2013091620A | 2013-05-16 | |||
| JP2015063469A | 2015-04-09 |
Other References:
後藤雅宏 他: "S/O技術を利用したドラッグデリバリーシステム", 薬剤学, vol. 73, no. 2, JPN6021033917, 2013, pages 93 - 100, ISSN: 0004582215
Attorney, Agent or Firm:
Hiroshi Kobayashi
Kyoko Tamura
Yasuhito Suzuki
Kyoko Tamura
Yasuhito Suzuki