Title:
NONSTEROIDAL LIGAND FOR GLUCOCORTICOID RECEPTOR, COMPOSITION THEREOF, AND USE THEREOF
Document Type and Number:
Japanese Patent JP2010132672
Kind Code:
A
Abstract:
To provide a method for treating or preventing obesity, diabetes, anxiety, depression, neurodegeneration, or inflammatory diseases.
There are provided a nonsteroidal ligand for glucocorticoid receptors, a method for producing a nonsteroidal ligand for glucocorticoid receptors, and methods for using a nonsteroidal ligand for glucocorticoid receptors and nonsteroidal ligand compositions. These are effective against diseases associated with the binding between a glucocorticoid and a glucocorticoid receptor, for examples, obesity, diabetes, depression, neurodegeneration, or inflammatory diseases.
COPYRIGHT: (C)2010,JPO&INPIT
Inventors:
SCANLAN THOMAS S
SHAH NILESH
SHAH NILESH
Application Number:
JP2010006117A
Publication Date:
June 17, 2010
Filing Date:
January 14, 2010
Export Citation:
Assignee:
UNIV CALIFORNIA
International Classes:
C07D231/54; A61K31/415; A61K31/416; A61K31/4162; A61K31/42; A61K31/423; A61K31/425; A61P3/04; A61P3/10; A61P5/44; A61P5/46; A61P25/00; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P43/00; C07D275/06; C07D317/72; C07D327/10; C07D339/06; C07D403/06; C07D409/06; C07D487/04
Foreign References:
| EP0102404A1 | 1984-03-14 | |||
| DE1169442B | 1964-05-06 | |||
| GB1071124B | ||||
| US3135743A | 1964-06-02 | |||
| GB934574B |
Other References:
JPN6009035459; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ３６（２２）, 1993, ｐｐ．３２７８-３２８５
JPN6009035461; Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ， Ｓｅｃｔｉｏｎ Ｂ： Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｉｎｃｌｕｄｉｎｇ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ３８Ｂ（７）, 1999, ｐｐ．８４７-８４９
JPN6009035464; Ｐｌａｎｔａ Ｍｅｄｉｃａ ６５（８）, 1999, ｐｐ．７７８-７７９
JPN6009035466; 薬学雑誌 ９３（３）, 1973, ｐｐ．２９６-２９９
JPN6009035469; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ｖｏｌ．２７, 1962, ｐｐ．２８００-２８０７
JPN6009035472; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３５（３６）, 1994, ｐｐ．６６４３-６６４６
JPN6009035475; Ｓｔｅｒｏｉｄｓ ５７（７）, 1992, ｐｐ．３０６-３１２
JPN6009035479; Ｊｏｕｒｎａｌ ｏｆ Ｓｔｅｒｏｉｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ ３６（１-２）, 1990, ｐｐ．１５３-１７４
JPN6009035481; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ４５（１４）, 1980, ｐｐ．２７４１-２７４６
JPN6009035483; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ［Ｓｅｃｔｉｏｎ］ Ｄ： Ｃｈｅｍｉｃａｌ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ｖｏｌ．５, 1971, ｐｐ．２３３-２３４
JPN6009035484; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ［Ｓｅｃｔｉｏｎ］ Ｃ： Ｏｒｇａｎｉｃ ｖｏｌ．１４, 1969, ｐｐ．１９３７-１９３９
JPN6009035487; Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ １６（８）, 1968, ｐｐ．１４８７-１４９７
JPN6009035490; Ｃａｎａｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ ４１（９）, 1963, ｐｐ．２２９４-２２９８
JPN6009035493; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４３（２２）, 2000, ｐｐ．４２３３-４２４６
JPN6009035495; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４３（９）, 2000, ｐｐ．１８６６-１８７７
JPN6009035498; Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ １６（２）, 1993, ｐｐ．１４２-１４５
JPN6009035500; Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ ５０（１２）, 1992, ｐｐ．８９１-８９７
JPN6009035461; Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ， Ｓｅｃｔｉｏｎ Ｂ： Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｉｎｃｌｕｄｉｎｇ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ３８Ｂ（７）, 1999, ｐｐ．８４７-８４９
JPN6009035464; Ｐｌａｎｔａ Ｍｅｄｉｃａ ６５（８）, 1999, ｐｐ．７７８-７７９
JPN6009035466; 薬学雑誌 ９３（３）, 1973, ｐｐ．２９６-２９９
JPN6009035469; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ｖｏｌ．２７, 1962, ｐｐ．２８００-２８０７
JPN6009035472; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３５（３６）, 1994, ｐｐ．６６４３-６６４６
JPN6009035475; Ｓｔｅｒｏｉｄｓ ５７（７）, 1992, ｐｐ．３０６-３１２
JPN6009035479; Ｊｏｕｒｎａｌ ｏｆ Ｓｔｅｒｏｉｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ ３６（１-２）, 1990, ｐｐ．１５３-１７４
JPN6009035481; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ４５（１４）, 1980, ｐｐ．２７４１-２７４６
JPN6009035483; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ［Ｓｅｃｔｉｏｎ］ Ｄ： Ｃｈｅｍｉｃａｌ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ｖｏｌ．５, 1971, ｐｐ．２３３-２３４
JPN6009035484; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ［Ｓｅｃｔｉｏｎ］ Ｃ： Ｏｒｇａｎｉｃ ｖｏｌ．１４, 1969, ｐｐ．１９３７-１９３９
JPN6009035487; Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ １６（８）, 1968, ｐｐ．１４８７-１４９７
JPN6009035490; Ｃａｎａｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ ４１（９）, 1963, ｐｐ．２２９４-２２９８
JPN6009035493; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４３（２２）, 2000, ｐｐ．４２３３-４２４６
JPN6009035495; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４３（９）, 2000, ｐｐ．１８６６-１８７７
JPN6009035498; Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ １６（２）, 1993, ｐｐ．１４２-１４５
JPN6009035500; Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ ５０（１２）, 1992, ｐｐ．８９１-８９７
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Katsuichi Nishimoto
Kato Kazunori
Katsuichi Nishimoto