PURPOSE: To obtain a novel nor-bile derivative obtained by bonding plural bile acid groups, having high affinity with a bile acid-transporting system of intestine, capable of inhibiting bile acid absorption and useful as antihyperlipidemic agents for reducing lipid in blood.
CONSTITUTION: This novel nor-bile acid derivative is expressed by the formula G1-X-G2 {G1 is a (modified) bile acid or the like of formula I [Z is a branched alkylene or a single bond; R(1) is H, a 1-10C alkyl, a 2-10C alkenyl, a (substituted) benzyl, a (substituted) phenyl or the like, R(2) to R(5) are each H, OL (L is H, a 1-10C alkyl, a 2-10C alkenyl, a phenyl or the like), both SL and NHL together form CO] or the like, G2 is a (modified) bile acid of formula II [V is O, NL, CH2 or the like; W is H or OH; Y is OL, NHL, NL2 or the like; R(6) to R(9) are each H, OL, SL, NHL or two of them together form CL] or the like; X is a bridge or a covalent bond}. The compound is obtained by reacting a G1-X in a reactive form with a G2 or a G2-X in a reactive form with a G1.
HAINAA GUROMUBIKU
BUERUNAA KURAAMAA
GIYUNTAA BUESU
