PURPOSE: To obtain a normalizing agent for cancerated cell having reduced toxicity, by using a herbimycin derivative as an active component.

CONSTITUTION: A compound of formula I [R1 and R2 are H, (CH3)2N, group of formula II, formula III or CH2=CH-CH2-NH; X-Y is group of formula IV or formula V] is used as an active component of the objective agent. The compound of formula I can be produced by reacting (A) herbimycin a of formula VI or a compound of formula VII obtained by converting the 8-site double bond of herbimycin A into epoxy group with (B) a substituted amine in an organic solvent at 0W50°C for 12W96hr.