Title:
NOVEL 1,3-DIARYLCYCLOPENTANE AND DERIVATIVES OF SAME AS THROMBOCYTE ACTIVATOR ANTAGONISTIC DRUG
Document Type and Number:
Japanese Patent JPS6366135
Kind Code:
A
Abstract:
Novel 1,3-Diaryl cyclopentanes were prepared. These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediated by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.
Inventors:
YUAN CHIN PII CHIAN
TESUFUAIE BIFUTSU
DONARUDO DABURIYU GURAHAMU
SHIYU SHIYU YANGU
MAIKERU ENU CHIYANGU
JIYON SHII CHIYABARA
KASURIN ERU TONPUSON
TESUFUAIE BIFUTSU
DONARUDO DABURIYU GURAHAMU
SHIYU SHIYU YANGU
MAIKERU ENU CHIYANGU
JIYON SHII CHIYABARA
KASURIN ERU TONPUSON
Application Number:
JP20802987A
Publication Date:
March 24, 1988
Filing Date:
August 21, 1987
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
C07C13/28; A61K31/09; A61K31/12; A61K31/135; A61K31/15; A61K31/165; A61K31/19; A61K31/275; A61K31/33; A61P7/00; A61P9/00; A61P11/00; A61P25/04; A61P29/00; A61P43/00; C07C1/00; C07C17/00; C07C19/01; C07C23/08; C07C25/18; C07C27/00; C07C29/143; C07C35/21; C07C41/00; C07C43/18; C07C43/20; C07C43/21; C07C43/215; C07C43/225; C07C43/23; C07C45/00; C07C45/48; C07C49/753; C07C49/76; C07C59/125; C07C59/72; C07C62/30; C07C62/34; C07C67/00; C07C69/708; C07C201/00; C07C209/00; C07C227/00; C07C227/16; C07C255/53; C07C275/04; C07C301/00; C07C303/26; C07C303/36; C07C309/28; C07C311/02; C07C311/13; C07C317/00; C07C323/20; C07C323/22; C07D265/36; C07D303/02; C07D317/48; C07D319/18; C07D521/00; (IPC1-7): A61K31/09; A61K31/12; A61K31/135; A61K31/15; A61K31/165; A61K31/19; A61K31/275; A61K31/33; C07/; C07C13/28; C07C19/02; C07C23/08; C07C25/18; C07C35/21; C07C43/18; C07C43/20; C07C49/76; C07C59/125; C07C62/30; C07C62/34; C07C69/708; C07C79/08; C07C87/455; C07C93/02; C07C101/14; C07C101/16; C07C101/18; C07C102/00
Attorney, Agent or Firm:
Masao Okabe
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