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Title:
NOVEL 19-NOR STEROID HAVING PHENOXYALKYLSULFON-AMIDE OR PHENOXYALKYLSULFONYL UREA CHAIN AT 11 BETA-POSITION, ITS PREPARATION, ITS INTER-MEDIATE, ITS USE AS PHARMACEUTICAL PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
Document Type and Number:
Japanese Patent JPH0717996
Kind Code:
A
Abstract:

PURPOSE: To provide the subject novel compounds having hormone activating property and useful in the treatment and prevention of osteoporosis, diabetes or the like.

CONSTITUTION: These compounds of formula I [wherein R17 represents OH, a 1-12C acyloxy or the like, R'17 represents H, a (substituted) 1-8C alkyl, (substituted) alkenyl or the like; R3 represents H or a 1-8C alkyl; R1 and R2 are each H, a (substituted) 1-8C alkyl, (substituted) 1-12C acyl, (substituted) aryl, (substituted) alalkyl or the like; n is of 1 to 18], for example N-butyl-5-[4-(3,17β-dihydroxyestra-1,3,5-(10)-t) phnoxy]pentanesulfonamide are obtained by reacting a compound of formula II with a compound of formula III (wherein X represents a halogen; RA and RA' are each R1 or R2) to obtain a compound of formula IV, reacting the compound of formula IV with an aromatizing agent and an acylating agent to provide a compound of formula V, and then reducing ketone functional group at 17-position and addition of a compound of formula VI (wherein M is a metal) or the like.


Inventors:
Nique, Francois
Teutsch, Jean-georges
Van, DE Velde Patrick
Application Number:
JP1994000156407
Publication Date:
January 20, 1995
Filing Date:
June 16, 1994
Export Citation:
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Assignee:
ROUSSEL UCLAF
International Classes:
A61K31/56; A61K31/565; A61K31/57; A61K31/575; A61K31/58; A61P1/00; A61P3/04; A61P3/08; A61P3/10; A61P5/00; A61P5/26; A61P5/28; A61P5/30; A61P5/32; A61P5/38; A61P5/42; A61P5/44; A61P5/46; A61P9/10; A61P9/12; A61P15/00; A61P15/04; A61P15/08; A61P17/00; A61P19/10; A61P25/20; A61P35/00; A61P37/04; A61P43/00; C07J1/00; C07J31/00; C07J41/00; C07J43/00; C07J75/00; (IPC1-7): C07J41/00; A61K31/56; A61K31/565; A61K31/57; A61K31/575; C07J1/00; C07J75/00
Attorney, Agent or Firm:
倉内 基弘 (外1名)