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Title:
NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVE
Document Type and Number:
Japanese Patent JP2014122211
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an GPR40 activator containing a compound having a novel GPR40 agonist effect or a salt thereof or a solvate thereof and the like as an active ingredient, especially an insulin secretion promoter, a prevention and/or therapeutic agent for diabetes, obesity and the like.SOLUTION: There is provided a compound represented by the formula (I), where p represents 0 to 4, j represents 0 to 1, k represents 0 to 2, a ring A represents an aryl group, a heterocyclic group, a cycloalkyl group, a cycloalkenyl group or a spirocyclic group may be substituted by L, a ring B represents an aryl group or heteroaryl group, X represents O or -NR-, and L, Rto Rrepresent specific groups, or a salt thereof or a solvate thereof.

Inventors:
OKOCHI MUNETAKA
Application Number:
JP2013239340A
Publication Date:
July 03, 2014
Filing Date:
November 19, 2013
Export Citation:
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Assignee:
MOCHIDA PHARMACEUT CO LTD
International Classes:
C07D275/02; A61K31/40; A61K31/403; A61K31/425; A61K31/427; A61K31/4439; A61K31/454; A61K31/4545; A61K31/496; A61K31/4985; A61K31/502; A61K31/506; A61K31/522; A61K31/5377; A61K45/00; A61P3/10; A61P43/00; C07D417/12; C07D417/14; C07D471/10; C07D491/107; C07D491/20; C07B57/00
Domestic Patent References:
JP2005015461A2005-01-20
JP5809157B22015-11-10
JP5420796B22014-02-19
JP5002077B22012-08-15
JP2005015461A2005-01-20
JP5809157B22015-11-10
JP5420796B22014-02-19
Foreign References:
WO2005035551A22005-04-21
WO2009147990A12009-12-10
WO2009123316A12009-10-08
WO2005035551A22005-04-21
WO2009147990A12009-12-10
WO2009123316A12009-10-08
Attorney, Agent or Firm:
萼 経夫
宮崎 嘉夫
加藤 勉