Title:
NOVEL 3-KETO-DELTA4,9-19-NORSTEROID DERIVATIVE
Document Type and Number:
Japanese Patent JPH02275895
Kind Code:
A
Abstract:
NEW MATERIAL: A compd. represented by formula I [wherein R1' is a (substd.) thienyl, furyl, a cycloalkyl or a (substd.) phenyl, R2 is methyl or ethyl, R3' is H, a (substd.) alkyl, an alkenyl or a (protected) acetyl, R4' is H, OH or a (substd.) 1-12C alkyl, R3" is H or methyl at an α- or β-position and K is a ketone blocked in a form of ketal, thioketal, oxime and methyloxime].
EXAMPLE: 17β-Hydroxy-17α-(1-propynyl)-11β-(2'-thienyl)estra-4,9-dien-3-one.
USE: This new material is useful for hypertension, atherosclerosis, osteoporosis, diabetes, obesity, immune depression and agrypnia.
PROCESS: A dehydrating agent capable of liberating a protected functional group is allowed to act on a compd. represented by formula II.
Inventors:
DANIERU FUIRIBEERU
JIYAN JIYORUJIYU TOUUCHI
JIERUMAN KOSUTORUUSU
ROJIE DORAE
JIYAN JIYORUJIYU TOUUCHI
JIERUMAN KOSUTORUUSU
ROJIE DORAE
Application Number:
JP4602390A
Publication Date:
November 09, 1990
Filing Date:
February 28, 1990
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
A61P5/00; A61P5/38; C07J1/00; C07J7/00; A61K31/56; C07J9/00; C07J17/00; C07J21/00; C07J31/00; C07J33/00; C07J41/00; C07J51/00; C07J53/00; C07J61/00; C07J71/00; (IPC1-7): A61K31/56; C07J1/00; C07J7/00; C07J9/00
Attorney, Agent or Firm:
Motohiro Kurauchi
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