Title:
新規なＰｑｓＲインバースアゴニスト
Document Type and Number:
Japanese Patent JP7421655
Kind Code:
B2
Abstract:
The present invention relates to a compound according to general formula (I), which acts as an inverse agonist of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS), sometimes also referred to as MvfR); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
Inventors:
Hamed Mostafa
Ahmed Ahmed S.A.
Emptying Martin
Schutz Christian
Hartmann Rolf W.
roerig teresa
Kany Andreas M
Hirsch Anna K.H.
Ahmed Ahmed S.A.
Emptying Martin
Schutz Christian
Hartmann Rolf W.
roerig teresa
Kany Andreas M
Hirsch Anna K.H.
Application Number:
JP2022540896A
Publication Date:
January 24, 2024
Filing Date:
December 30, 2020
Export Citation:
Assignee:
Helmholtz-Zentrum fur Infektionsforschung GmbH
International Classes:
C07D401/14; A61K31/4439; A61K31/497; A61K31/501; A61K31/506; A61K45/00; A61L27/28; A61L29/08; A61L31/08; A61P11/00; A61P31/04; A61P43/00; C07D403/14; C07D417/14
Domestic Patent References:
| JP2002510293A | ||||
| JP2018535949A | ||||
| JP2008519021A | ||||
| JP2021529203A |
Foreign References:
| WO2008098143A1 |
Other References:
PLoS Pathogens,2014年,Vol.10(8),e1004321(p.1-17)
Attorney, Agent or Firm:
Patent Attorney Corporation Iida and Partners
Toshizo Iida
Shuichi Akabane
Hirokazu Hoshino
Takashi Goto
Ikuo Shinoda
Toshizo Iida
Shuichi Akabane
Hirokazu Hoshino
Takashi Goto
Ikuo Shinoda