Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL ACONITINE-BASED COMPOUND AND ANALGESIC AND ANTIPHLOGISTIC AGENT
Document Type and Number:
Japanese Patent JPH03223255
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by formula I [R1 is (substituted) saturated or unsaturated alkyl, H, (substituted)aliphatic or aromatic acyl or (substituted) aralkyl; R3 to R6 are H or OH, R5 is acetoxy; R6 and carbon at 15 position together form CO; with the provisos (i) when R1 is benzoyl, R2 is methyl, R3 is H or OH and R4 and R6 are OH, R5 represents H; (ii) when R1 is benzoyl, R2 is methyl, R3 and R4 are H and R6 is OH, R5 represents H; (iii) when R1 is anisoyl, R2 is ethyl, R3 is H, R4 and R6 are OH, R5 represents H or OH; etc.].

EXAMPLE: 8-Deoxy-14-O-ansoylaconi ne, 3-deoxyjesaconitine, etc.

USE: The compound of formula I is employed in the form of tablets, capsules, etc., for oral administration, in the form of preparations for injection or in the form of suppositories for intrarectal administration as an analgesic anti-inflammatory drug in a dose of 1-1000 mg/day for an adult.

PREPARATION: The compound of formula I is prepared by subjecting the 3, 8, 13 or 15 position of an aconitine compound of formula II (R1 is Bz, An; R2 is CH2CH3, CH3, etc.,), etc., as a starting material to a deoxidizing reaction, by subjecting a N-substituent or 14-substituent of the compound of formula II with any other substituent or by other methods.


Inventors:
Murayama, Mitsuo
Mori, Takao
Application Number:
JP1990000283553
Publication Date:
October 02, 1991
Filing Date:
October 23, 1990
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SANWA SHIYOUYAKU KK
International Classes:
C07D221/22; A61K31/435; A61K31/485; A61P25/04; A61P29/00; (IPC1-7): A61K31/435; C07D221/22