NOVEL ALKYLAMINOPROPANOL DERIVATIVE

Japanese Patent JPS5859957

A

Compounds of the formula wherein R1 is cycloalkyl of 3 to 10 carbon atoms; phenyl; mono- or poly-substituted phenyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (-CH=CH-)2 or -O-CH2-O- attached to vicinal carbon atoms of the phenyl ring; aryloxy-lower alkyl; (mono- or poly-substituted aryl)-oxy-lower alkyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (-CH=CH-)2 or -O-CH2-O- attached to vicinal carbon atoms of the phenyl ring; R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or the ring-forming group (-CH=CH)2 or -(CH2)n-, where n is an integer from 3 to 5, attached to vicinal carbon atoms of the phenyl ring; and R3 is straight or branched alkyl of 1 to 10 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful for the treatment of tachycardia, hypertension and coronary diseases.

HERUBERUTO KETSUPE
BERUNAA KUMAA
HERUMUTSUTO SUTAARE
GOYUKO MUASEBITSUKU
BERUNAA TORAUNETSUKAA

JP14751882A

April 09, 1983

August 25, 1982

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BOEHRINGER INGELHEIM KG

A61K31/135; A61K31/16; A61K31/335; A61K31/275; A61K31/357; A61K31/36; A61P9/00; A61P9/08; A61P9/10; A61P9/12; C07C33/00; C07C67/00; C07C253/00; C07C253/30; C07C255/59; C07C255/60; C07D317/60; C07D317/68; A61K; C07C; (IPC1-7): A61K31/275; A61K31/36; C07C121/80; C07D317/68

Hideto Asamura

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