NOVEL ALKYLENEDIAMINE DERIVATIVE AND GLUTAMIC ACID BLOCKER

Japanese Patent JPH01265080

A

NEW MATERIAL:An alkylenediamine derivative expressed by the formula (R1 is H, aliphatic hydrocarbon, alicyclic hydrocarbon, aryl, aryl-substituted alkyl, etc.; Y is O or S; R2 is aliphatic hydrocarbon, aryl-substituted alkyl, etc.; R3-R5 are H, alkyl, alkoxy, acyl, acyloxy, aryl, aralkyl OH, halogen, nitrile, etc.; p is 2-10; q is 4-7) or salt thereof.

EXAMPLE: N-(2-Hydroxy-2-phenylethyl)-N-(3-piperidinopropyl)heptan-amide.

USE: A glutamic acid blocker, remedy for neuropathy and agricultural chemicals (capable of blocking neuromuscular junctions of insects and diminishing activity thereof).

PREPARATION: For example, 2-amino-1-phenylethane-1-ol is obtained from α- aminoacetophenone and passed through N-(2-hydroxy-2-phenylethyl)-N-(3- piperidinopropy)heptanamide to afford the exemplified compound.

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MAZAKI MITSUO
MORIFUJI NAOYA
HASHIMOTO KOICHI
SHINOZAKI ATSUHIKO

JP9268488A

October 23, 1989

April 15, 1988

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NIPPON CHEMIPHAR CO

C07D295/12; A61K31/395; A61K31/40; A61K31/445; A61K31/55; A61P25/00; C07D223/04; C07D223/06; C07D223/08; C07D223/12; C07D225/02; (IPC1-7): A61K31/395; A61K31/40; A61K31/445; A61K31/55; C07D223/04; C07D223/06; C07D223/08; C07D223/12; C07D225/02; C07D295/12

JPS5455544A	1979-05-02
JPS62277372A	1987-12-02

Yasuo Yanagawa

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