Title:
NOVEL AMIDINO TRICYLIC DERIVATIVE
Document Type and Number:
Japanese Patent JPH01132567
Kind Code:
A
Abstract:
New pharmacologically active amidino tricycle derivatives as muscarinic receptor blocking agents, useful for the treatment of gastrointestinal disorders of the following formula: wherein R represents a hydrogen atom or a halogen atom X represents nitrogen or -CH-group W represents a -NH-CO-, -CH=CH-, -CH2-CH2- group, oxygen or sulfur R1 represents a hydrogen atom or a C1-4 alkyl group n is 0 or 1 Y represents sulfur or a -CH- group A represents carbon or nitrogen B represents a -CH- group (provided that A is different from nitrogen), -COO-, -CO-, or -CH2- group m is 0 or an integer from 1 to 3 Z represents -NH-, -CO-, -COO- or -CH- group, or it is absent p is 0 or 1 Het represents piperazinyl, homopiperazinyl, piperidinyl, tropyl or tetrahydropirimidinyl group, each group being optionally substituted by a C1-4 alkyl group or an amino group q is 0 or 1 R2 represents a hydrogen atom, a C1-4 alkyl group or an amino group optionally substituted by a linear or branched C1-4 alkyl group or phenyl group R3 represents a linear or branched C1-8alkyl group or a hydrogen atom (provided that the bond between Het and the group is a carbon- carbon bond or A=C and B=CH), or R2 and R3 may join together to form a heterocyclic 5-membered ring, tautomers thereof and acid addition salts of the aforesaid compounds. The process for the preparation of the compounds of formula (I) as well as pharmaceuticals compositions containing them are also described.
Inventors:
MARUKO TOURUKOONI
ARUTEYURO DONETSUTEI
ENTSUO CHIEREDA
MIRUNA JIRU KUINTERO
JIOBUANBATSUCHISUTA SHIABUI
ROSAMARIA MIKERETSUCHI
ARUTEYURO DONETSUTEI
ENTSUO CHIEREDA
MIRUNA JIRU KUINTERO
JIOBUANBATSUCHISUTA SHIABUI
ROSAMARIA MIKERETSUCHI
Application Number:
JP23617888A
Publication Date:
May 25, 1989
Filing Date:
September 20, 1988
Export Citation:
Assignee:
ANGELI INST SPA
International Classes:
A61K31/435; A61K31/46; A61K31/535; A61K31/538; A61K31/55; A61K31/551; A61P1/04; A61P1/10; A61P1/12; A61P1/16; A61P13/02; A61P15/00; A61P21/02; A61P25/02; C07D221/16; C07D223/20; C07D223/22; C07D223/24; C07D223/26; C07D223/28; C07D223/32; C07D243/38; C07D265/38; C07D243/14; C07D311/84; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D409/06; C07D409/12; C07D451/02; C07D451/04; C07D471/04; C07D495/04; C07D495/14; C07D498/04; C07D513/04; C07D519/00; (IPC1-7): A61K31/435; A61K31/46; A61K31/535; A61K31/55; C07; C07D221/16; C07D223/20; C07D223/22; C07D223/24; C07D223/32; C07D243/14; C07D265/38; C07D311/84; C07D401/12; C07D403/06; C07D403/12; C07D409/06; C07D409/12; C07D451/04; C07D471/04; C07D495/04; C07D495/14; C07D498/04
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)
Previous Patent: 4-AMINOPYRIDINE DERIVATIVE
Next Patent: AROMATASE INHIBITING SUBSTITUTED 4(5)-IMIDAZOLE
Next Patent: AROMATASE INHIBITING SUBSTITUTED 4(5)-IMIDAZOLE