Title:
NOVEL AMINOGUANIDINE DERIVATIVE AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS60178855
Kind Code:
A
Abstract:
The invention relates to new aminoguanidine derivatives of the general formula (I), I wherein R1, R2 and R3 each represent hydrogen or halogen atom, C1-4 alkyl, nitro, trifluoromethyl or C1-4 alkoxy group, R4 and R5 represent a C1-4 alkyl group, furthermore NR4R5 may form a 5 to 7 membered saturated heterocyclic group containing either one or two nitrogen atoms or a nitrogen and an oxygen atom and being optionally substituted by one or two methyl, hydroxymethyl or hydroxyethyl groups, R6 and R7 each represent a hydrogen atom, normal or branched C1-4 alkyl or C2-4 alkenyl group, and to their pharmaceutically acceptable acid addition salts as well as to a process for the preparation thereof. The new compounds of the invention possess valuable antiarrhythmic activity and are devoid of the undesired circulatory side effects of the known antiarrhythmic compounds.
Inventors:
ISUTOBAN ERUTSUI
IENO MAROSUFUARUBI
JIYORUGII RABUROTSUKII
ANDORASU BATSURO
MARIA KUHARA
ISUTOBAN EREKESU
RASUZURO SUZATOMARII
RASUZURO YASUZURITSU
IENO MAROSUFUARUBI
JIYORUGII RABUROTSUKII
ANDORASU BATSURO
MARIA KUHARA
ISUTOBAN EREKESU
RASUZURO SUZATOMARII
RASUZURO YASUZURITSU
Application Number:
JP26099684A
Publication Date:
September 12, 1985
Filing Date:
December 12, 1984
Export Citation:
Assignee:
BIOGAL GYOGYSZERGYAR
International Classes:
A61K31/155; C07C281/16; A61K31/40; A61K31/445; A61K31/495; A61K31/535; A61K31/5375; A61K31/55; A61P9/06; C07C281/10; C07D211/10; C07D265/30; C07D295/14; C07D295/215; (IPC1-7): C07C133/10
Attorney, Agent or Firm:
Aoki Akira