Title:
NOVEL AMINOPROPANOL DERIVATIVE* ITS MANUFACTURE AND THERAPEUTIC CONTAINING SAME FOR CARDIAC AND CIRCULATORY DISEASE
Document Type and Number:
Japanese Patent JPS55162783
Kind Code:
A
Abstract:
An aminopropanol compound of the formula wherein R1 and R2 are individually selected from hydrogen and lower alkyl; or R1 and R2 together represent an alkylene radical; R3 is hydrogen or acyl; A is one of the following structures wherein R4 is hydrogen or lower alkyl optionally substituted by hydroxyl halogen and lower alkylthio; and R5 and R6 are individually selected from lower alkyl; B is alkylamino which optionally carries a phenyl and a phenoxy radical optionally substituted by at at least one of halogen, hydroxyl or lower alkyl, lower acyl, lower alkylthio, acylamino, aminocarbonyl, lower alkoxy, lower alkenyloxy, phenoxy, lower alkenyl, lower alkylsulphonyl, lower alkylsulphinyl or haloalkyl; or B is an aryl- or heteroaryloxymethylpiperidine radical optionally substituted by at least one of halogen hydroxyl or lower alkyl, hydroxyl alkyl or carboxamido alkyl, or by lower alkoxy, lower acyl, amino, carboxamido, lower alkylcarbonylamido or lower alkylsulphonylamino; and the pharmacologically acceptable salts thereof, are outstandingly effective beta blockers and blood-pressure depressants.
Inventors:
KAARU HAINTSU ROSU
BUORUFUGANGU KAMUPE
BUORUFUGANGU BARUCHIYU
GISUBERUTO SHIYUPONAA
EEGON RETSUSHIYU
BUORUFUGANGU KAMUPE
BUORUFUGANGU BARUCHIYU
GISUBERUTO SHIYUPONAA
EEGON RETSUSHIYU
Application Number:
JP7164680A
Publication Date:
December 18, 1980
Filing Date:
May 30, 1980
Export Citation:
Assignee:
BOEHRINGER MANNHEIM GMBH
International Classes:
A61K31/495; A61K31/505; A61P9/00; C07D241/38; C07D241/44; C07D401/12; C07D401/14; C07D211/22; C07D213/64; C07D235/26; (IPC1-7): A61K31/505; C07D241/38; C07D241/44; C07D401/12; C07D401/14