Title:
NOVEL BENZO(B)THIPHENES, BENZO(B)FURANS, THIOCHROMANS AND CHROMANS, MANUFACTURE AND BACTERICIDAL COMPOSITION CONTAINING SAME
Document Type and Number:
Japanese Patent JPS57131787
Kind Code:
A
Abstract:
Compounds of the formula
wherein n is 0 or an integer from 1 to 4;
p is 0 or 1;
q is 0, 1 or 2,
R and R<1> are independently hydrogen or halogen atoms, or lower alkyl, halolower alkyl, nitro or NR<2>R<3> groups, wherein R<2> and R<3> are independently hydrogen atoms or lower alkyl groups; or R and R<1> together in adjacent positions complete a fused saturated or unsaturated carbocyclic ring that may contain 5 to 7 carbon atoms;
X is an oxygen or sulfur atom or a sulphinyl or sulphonyl group;
Y is an imidazolyl or 1,2,4-triazolyl group, either of which may be substituted by a lower alkyl or aryl group, wherein said aryl group is a phenyl, halophenyl or lower alkyl phenyl group;
Z is an alkyl, alkenyl, alkynyl, cycloalkyl or heterocyclic aromatic group, which may have at least one substituent selected from halogens atoms and lower alkyl, lower alkoxy, lower alkylidenedioxy, phenyl and N-(N min -lower alkanoyl-piperazinyl) groups, provided that, when n is 0, Z is not 1-alkynyl; and, when n is 1 to 4, Z can also be an alkoxy, alkylthio, aryl, aryloxy or arylthio group, or an aryl, aryloxy or arylthio group having substituents selected from halogen atoms and lower alkyl, lower alkoxy, lower alkylidenedioxy and N-(N min -lower alkanoyl-piperazinyl)- groups;
where the term "lower" indicates groups having 1 to 6 carbon atoms; and the broken line indicates a single or double bond, with the proviso that it is a double bond only when p is 0 and X is a sulfur atom;
and the acid addition salts thereof;
have antimicrobial, in particular antifungal, antibacterial and antiprotozoal activity. Compositions, especially pharmaceutical compositions, containing them and processes for their preparation are also disclosed.
Inventors:
DEINANATOO FUAKIRU RANE
JIYON JIETSUSEN RAITO
RATSUSERU EDOUIN PAIKU
JIYON JIETSUSEN RAITO
RATSUSERU EDOUIN PAIKU
Application Number:
JP19995781A
Publication Date:
August 14, 1982
Filing Date:
December 11, 1981
Export Citation:
Assignee:
SCHERING PLOUGH CORP
International Classes:
A01N43/14; A01N43/16; A01N43/18; A01N43/40; A01N43/50; A01N43/56; A01N43/653; A01N43/78; A01N43/824; A61K31/335; A61K31/38; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/47; A61P31/04; A61P33/02; C07D231/12; C07D295/185; C07D335/06; C07D405/02; C07D405/06; C07D405/14; C07D409/02; C07D409/06; C07D409/14; C07D413/12; C07D413/14; C07D417/14; A01N43/12; C07D491/056; C07D521/00; (IPC1-7): C07D405/06; C07D409/06; C07D409/14; C07D413/14; C07D417/14; C07D491/052