NOVEL BICYCLIC COMPOUND, PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUND

Title:

NOVEL BICYCLIC COMPOUND, PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUND

Document Type and Number:

Japanese Patent JPS63301840

Kind Code:

A

Abstract:

NEW MATERIAL:A bicyclic compound expressed by formula I (A is =C=O or =CHOH; R1 is aryl which may have cyano or carbamoyl or heterocyclic ring which have alkyl; R2 is H or lower alkyl; R3 is lower alkyl; X is H, halo gen, OH or lower alkyl; m is 1 or 2; n is 1W4) and salts thereof.

EXAMPLE: (+)-2,2-Dibutyl-5-(2-quinolylmethoxy)-1,2,3,4-tetrahydro-1-naphthol.

USE: An anti-inflammatory agent, antiallergic agent, etc., having inhibitory action on 5-lipoxygenase.

PREPARATION: For example, a compound expressed by formula II or salt thereof is reacted with a compound expressed by formula III or salt thereof to afford the aimed compound expressed by formula I.

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Inventors:

OKU TERUO
KAWAI YOSHIO
KAYAGIRI HIROSHI
KURATANI KAZUYOSHI
HASHIMOTO SHINJI

Application Number:

JP10230788A

Publication Date:

December 08, 1988

Filing Date:

April 25, 1988

Export Citation:

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Assignee:

FUJISAWA PHARMACEUTICAL CO

International Classes:

A61K31/085; A61K31/12; A61K31/165; A61K31/275; A61K31/33; A61K31/415; A61K31/4184; A61K31/425; A61K31/428; A61K31/44; A61K31/4409; A61K31/4418; A61K31/47; A61P1/00; A61P1/16; A61P9/08; A61P9/10; A61P13/02; A61P15/00; A61P29/00; A61P37/08; A61P43/00; C07C41/00; C07C41/01; C07C41/26; C12N9/99; C07C43/23; C07C45/00; C07C45/67; C07C45/68; C07C46/00; C07C49/747; C07C49/755; C07C50/12; C07C67/00; C07C231/00; C07C231/06; C07C231/12; C07C235/20; C07C235/42; C07C253/00; C07C253/30; C07C255/32; C07C255/52; C07C255/54; C07D213/30; C07D213/64; C07D215/14; C07D215/20; C07D215/26; C07D231/12; C07D235/08; C07D235/12; C07D237/08; C07D239/26; C07D277/64; C07D277/68; C07D521/00; C07F7/18; (IPC1-7): A61K31/085; A61K31/12; A61K31/165; A61K31/275; A61K31/33; A61K31/415; A61K31/425; A61K31/44; A61K31/47; C07C41/01; C07C41/26; C07C43/23; C07C49/755; C07C102/08; C07C103/26; C07C121/64; C07D213/64; C07D215/14; C07D231/12; C07D235/12; C07D237/08; C07D239/26; C07D277/64; C07D521/00; C12N9/99

Foreign References:

US4096267A

1978-06-20

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