Title:
NOVEL BICYCLOOCTANE DERIVATIVE
Document Type and Number:
Japanese Patent JPS54119441
Kind Code:
A
Abstract:
NEW MATERIAL:A bicyclooctane devivative of formula I: (R is 4W7C alkyl group; R1 is H or lower alkyl group; X is vinylene or ethylene chain; A is lowe alkylene or single bond).
EXAMPLE: Bicyclo[2.2.1] heptane-endo-2-hydroxymethyl-endo-3-caroboxy -endo-5- hydroxymethyl-γ-lactone.
USE: Medicines expected to have anti-agglutinating actions on the blood platelet.
PROCESS: A compound of formula II: (Y is H or OH-protecting group) is reacted with a phosphorane of formula III: (R' is aryl group) prepared from the witting reagent in the presence of a solvent, e.g. diethyl ether, and, if present, the OH- protecing group is removed, and , if desired, the reaction product is esterified to give the objective compound of formula I.
Inventors:
SHIMOMURA HIROI
SUGIE AKIHIKO
KATSUBE SUMIMOTO
YAMAMOTO HISAO
SUGIE AKIHIKO
KATSUBE SUMIMOTO
YAMAMOTO HISAO
Application Number:
JP2733278A
Publication Date:
September 17, 1979
Filing Date:
March 09, 1978
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO
International Classes:
A61K31/19; A61K31/215; A61P43/00; C07C45/67; C07C45/71; C07C69/732; C07C49/513; C07C49/743; C07C49/753; C07C51/00; C07C59/46; C07C62/32; C07C62/34; C07C67/00; C07C405/00; C07D307/93; C07D311/94; C07D317/72; (IPC1-7): A61K31/19; A61K31/215; C07C61/32; C07C69/74