NOVEL CARBAPENEM TYPE ANTIBIOTIC AND ITS PREPARATION

Title:

NOVEL CARBAPENEM TYPE ANTIBIOTIC AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS57108091

Kind Code:

A

Abstract:

NEW MATERIAL:A compound shown by the formulaI(R is H or sulfonic group; X is iodine atom), its salt or ester.

EXAMPLE: Disodium salt of (5R,6R)-3-(2-acetamido-1-iodoethenylsulfinyl)-6-(2-hydroxysulfonyloxy-2-propyl)-7-oxo-1-azabicyclo[3,2,0]hepto-2-ene-2-carboxylic acid.

USE: An antibacterial agent. Having antibacterial activity and β-lactamase inhibiting action, and high stability in a living body.

PROCESS: A compound shown by the formula II or its salt or ester is reacted with an iodinating agent (e.g., I2, ICl) to give a compound shown by the formulaI. The reaction is preferably carried out in an inert solvent (e.g., CH2Cl2) in the presence of a base (e.g., TEA) at a low temperature of -100W0°C.

Inventors:

NAKAYAMA MASATO
KIMURA SHIGERU
MIZOGUCHI TOSHIMI
TANABE SOUHEI
MORI TOSHITO

Application Number:

JP18468880A

Publication Date:

July 05, 1982

Filing Date:

December 25, 1980

Export Citation:

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Assignee:

KOWA CO

International Classes:

C07D477/00; A61K31/397; A61K31/40; A61P31/04; C07D487/04; (IPC1-7): A61K31/40; C07D487/04

Previous Patent: NOVEL NORTROPANE AND GRANATANE DERIVATIVES, MANUFACTURE AND USE AS MEDICINE

Next Patent: 7-OXO-4-THIA-1-AZA(3,2,0)HEPTANE AND 7-OXO-4-THIA-1-AZA(3,2,0)HEPT-2-ENE DERIVATIVE