NOVEL CARBOXYLIC ACID DERIVATIVE, MANUFACTURE AND BLOOD LIPID LEVEL LOWERING AGENT CONTAINING SAME

Japanese Patent JPS5872575

A

The present invention is concerned with new carboxylic acid derivatives, with processes for the preparation thereof and with pharmaceutical compositions for lipid depression and thrombocyte aggregation, containing them, and to methods for treating infirmaties caused by excess lipids or thrombocyte aggregation. The new carboxylic acid derivatives according to the present invention are compounds of the general formula: (I) wherein A is a valency bond or a lower alkylene chain, B is a valency bond or a saturated or unsaturated lower alkylene chain, R is hydrogen, an alkyl group which can be substituted by hydroxyl, carboxyl, sulphonic acid or optionally substituted phenoxy group, or R is an aralkyl radical, the aryl moiety of which can be substituted and the alkyl moiety of which is optionally unsaturated and can contain up to 4 carbon atoms, or R is a phenacyl radical, the phenyl moiety optionally substituted, or R is an acyl radical derived from aliphatic, araliphatic or aromatic carboxylic or sulphonic acid, or R is an aryl radical optionally substituted with the proviso that when A is a valency bond, R cannot be hydrogen, methyl, ethyl, hydroxyethyl, benzyl or phenyl, and the physiologically acceptable salts, esters and amides thereof.

ERUNSUTOOKURISUCHIAN BUITSUTE
HANSU PEETAA BUORUFU
BERUNTO HAAGENBURUUFU
KAARUHAINTSU SHIYUTEEKUMAIAA
YOHANESU PIRU

JP17407282A

April 30, 1983

October 05, 1982

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BOEHRINGER MANNHEIM GMBH

C07D295/02; A61K31/495; A61P7/00; C07D295/06; C07D295/08; C07D295/096; C07D295/112; C07D295/14; C07D295/15; C07D295/155; C07D295/18; C07D295/185; C07D295/192; C07D295/194; C07D295/20; C07D295/205; C07D295/22; C07D295/26; (IPC1-7): A61K31/495; C07D295/02; C07D295/06; C07D295/08

Toshio Yano

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