Title:
NOVEL CARBOXYLIC ACID ESTERS OF BETA-LACTAM ANTIBIOTIC
Document Type and Number:
Japanese Patent JPS5920286
Kind Code:
A
Abstract:
Compounds of formula wherein R1 is hydrogen, halogen or an organic group; R2 and R3, being the same or different, are hydrogen or an organic group; R4 is an aromatic or heteroaromatic, monocyclic or bicyclic ring, unsubstituted or substituted by one or more substituents chosen from: C1- C6 alkyl, C1-C6 alkoxy, formyl phenyl, phenoxy, C2-C6 alkanoyl, benzoyl, C1-6 alkoxycarbonyl, amino optionally substituted by one or two C1-C6 alkyl, formylamino, C2-C6 acylamino, benzoyl-amino, halogen and nitro; the symbol -E- represents -O-; -S- or -CH2-; X is oxygen or sulphur; and the symbol ---Y) represents a group completing, with the group -E- and the fused azetidinone ring, the skeleton of a b-lactam antibiotic; and the salts thereof. These esters can be readily hydrolysed to the corresponding free acids which have a broad spectrum anti-bacterial activity.
Inventors:
MARUKO ARUPEJIAANI
ANJIERO BEDESUKI
ETSUTORE PEROONE
KARUMERO GANDORUFUI
ANJIERO BEDESUKI
ETSUTORE PEROONE
KARUMERO GANDORUFUI
Application Number:
JP11720583A
Publication Date:
February 01, 1984
Filing Date:
June 30, 1983
Export Citation:
Assignee:
ERBA CARLO SPA
International Classes:
C07D499/897; A61K31/43; A61P31/04; C07C43/215; C07C43/225; C07C205/37; C07D403/12; C07D499/00; C07D499/04; C07D499/06; C07D499/32; C07D499/44; C07D499/86; C07D499/861; C07D499/87; C07D499/88; C07D501/20; C07D501/22; C07F7/18; (IPC1-7): A61K31/43; A61K31/545; C07D499/00; C07D501/22
Attorney, Agent or Firm:
Chika Takagi