Title:
NOVEL CARBOXYLIC DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5566577
Kind Code:
A
Abstract:
NEW MATERIAL:Carboxylic derivatives of formula I (A is O, S; R1 is H, methyl; R2 is hydroxyl, amino) and their nontoxic salts.
EXAMPLE: 2-[10,11-Dihydro-11-hydroxybenz(b,f)apin-2-yl]propioic acid.
USE: They have anti-inflammatory activity and are used as anti-inflammatory. They may orally or non-orally be administered.
PREPARATION: The reduction of a compound of formula II is effected in an organic solvent as alcohol or ether using a reducing reagent as sodium borohydride to give the compound of formula I. The nontoxic salt is, e.g., a metal salt of sodium or calcium or amine salt.
Inventors:
FUJIMOTO YASUO
YAMABE SHIGERU
YAMABE SHIGERU
Application Number:
JP13892878A
Publication Date:
May 20, 1980
Filing Date:
November 13, 1978
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO
International Classes:
C07D337/14; A61K31/335; A61K31/34; A61K31/38; A61P29/00; C07D313/14; (IPC1-7): A61K31/34; A61K31/38; C07D313/14; C07D337/14