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Title:
NOVEL CEPHALOSPORIN ANTIBIOTIC AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP2934809
Kind Code:
B2
Abstract:

PURPOSE: To provide a novel compd. excellent in antibacterial power and useful as an antibiotic.
CONSTITUTION: This compd. is represented by formula I [wherein R1 is H or an amino protecting group; R2 and R3 are each H or an OH protecting group or combined together to form a cyclic diol protecting group; R4 and R5 are each H or a carboxyl protecting group; R6 and R7 are each H, (substd.) amino, OH, 1-4C alkyl or the like when X and Y are each N or C and R7 is H or amino when X and Y are each C or N; and Q is =CH- or =N-], for example 7-[(Z)-2-(2-aminothiazol-4-yl)-2-((R)-α-carboxy-3,4- dihydroxybenzyloxyimino)acetamide]-3-(4,6-diaminopyridin-2-yl)-thiomethyl-3- cephem-4-carboxylate. The compd. represented by formula I is obtained by reacting a compd. represented by formula II (wherein L is a leaving group; and (m) is 0 or 1) with a compd. represented by formula III in the presence of a solvent and, if necessary, deprotecting or reducing S→(O)m.


Inventors:
YO ZAIKO
HO SANSHOKU
HAYASHI SHOSAN
U EIBIN
YANA TOKUHIRO
KIN SEIHO
DEN ZAIKUN
JO YOSHIKAGE
KIN SANSHOKU
RI TAIKI
KIN YOCHU
GO KENSHO
Application Number:
JP21692494A
Publication Date:
August 16, 1999
Filing Date:
September 12, 1994
Export Citation:
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Assignee:
RATSUKII KK
International Classes:
A61K31/546; C07D501/00; C07D501/04; C07D501/36; (IPC1-7): C07D501/36; C07D501/04
Domestic Patent References:
JP5112574A
JP6277392A
JP327388A
JP5508625A
Attorney, Agent or Firm:
Eiji Saegusa (4 others)