Title:
炎症性の疾患および病態を治療する新規な化合物、組成物および方法
Document Type and Number:
Japanese Patent JP4790263
Kind Code:
B2
Abstract:
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, S represents a steroid subunit (steroid moiety) derived from steroid drug with anti-inflammatory activity and L represents a linker molecule linking M and S, (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory diseases and conditions in humans and animals. Such compounds inhibit many cytokines and immune mediators involved in immune responses which cause inflammation, allergy, or alloimmunity, including without limitation IL-1, 2, 4, 5, 6, 10, 12, GMCSF, ICAM, and TNF-alpha. Importantly, anti-inflammatory steroids exert a direct anti-inflammatory effect through binding to the glucocorticosteroid receptor.
Inventors:
Muraden Mercep
Milan Mesic
Linda Tomaskovich
Stribol Malkovich
Oresta Macalha
Visnya polyak
Milan Mesic
Linda Tomaskovich
Stribol Malkovich
Oresta Macalha
Visnya polyak
Application Number:
JP2004519021A
Publication Date:
October 12, 2011
Filing Date:
July 08, 2003
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K31/7048; C07J43/00; A61K31/58; A61K31/7052; A61P1/04; A61P5/44; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P27/02; A61P29/00; A61P37/00; C07H17/00; C07H17/08; C07J21/00
Domestic Patent References:
| JP2004518670A | 2004-06-24 | |||
| JP2000508923A | 2000-07-18 |
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Nishino Mitsuru
Mizuhara Masahiro
Takuji Yamada
Michiko Matsutani
Nishino Mitsuru
Mizuhara Masahiro