NOVEL CYCLOBUTANE DERIVATIVE AND ITS PRODUCTION

Japanese Patent JP2632646

B2

PURPOSE: To provide a novel cyclobutane derivative useful as a synthetic intermediate for cyclobutane derivatives effective as antiviral agents or carcinostatic agents.
CONSTITUTION: A cyclobutane derivative is expressed by formula I [R1 is 1-5C alkyl, aralkyl; two R1 groups are combined to each other to form a 2-3C cyclic alkylene; R2 is H, 1-5C alkyl, protected hydroxyalkyl, protected carboxyl; R is H, 1-5C alkyl, 1-5C alkoxy, aralkyloxy; A is 2-5C alkylene; Y is O, S; Z is (substituted)methylene, O, S], e.g. (-)-(2S,3S)-3-methoxycarbonyl-1,1-bis(methylthio)-2-(oxazolidine-2-on-3-yl) carbonylcyclobutane. The compound of formula I is obtained by subjecting a compound of formula II and a compound of formula III to a condensing circulation treatment. The compound of formula I is useful as an intermediate for synthesizing a cyclobutane derivative of formula IV (B is the base of nucleic acid; R4 is H, protecting group).

ICHIKAWA JUICHIRO
NARITA FUMI
MATSUO KAORU
AOYAMA KEIKO
MATSUMURA FUMIKO
NISHAMA YUKIHIRO
MATSUBARA KENICHI
NAGAHATA TAKEMITSU
HOSHINO KORO
SEKI JUNICHI
NARASAKA KOICHI
HAYASHI JUJIRO

JP16859494A

July 23, 1997

June 29, 1994

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NIPPON KAYAKU KK

C07D239/54; A61K31/395; A61K31/496; A61K31/505; A61K31/52; A61K31/54; A61K31/55; A61K31/554; A61P31/12; A61P35/00; C07D207/24; C07D207/27; C07D263/16; C07D263/26; C07D265/08; C07D265/10; C07D267/06; C07D267/22; C07D277/14; C07D277/16; C07D279/06; C07D281/02; C07D281/18; C07D473/34; (IPC1-7): C07D207/24; A61K31/395; A61K31/54; A61K31/55; C07D207/27; C07D263/16; C07D263/26; C07D265/08; C07D265/10; C07D267/06; C07D267/22; C07D277/14; C07D277/16; C07D279/06; C07D281/02; C07D281/18

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