Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL FORTIMICIN B DERIVATIVE
Document Type and Number:
Japanese Patent JPS5973597
Kind Code:
A
Abstract:

NEW MATERIAL:A compound (salt) expressed by formula I [R3 is a protecting group of the amino group; Z is H, formula II (R2' is alkyl, hydroxyalkyl, carbamoylaminoalkyl, N-alkylaminoalkyl, N-alkylaminohydroxyalkyl or substituted aminoalkyl, etc.) or -CH2R2'].

EXAMPLE: 1,2',6'-Tri-N-benzyloxycarbonyl-(4-N-acetyl)fortimicin B.

USE: An antimicrobial agent.

PROCESS: Fortimicin B expressed by formula III is reacted with a reagent for protecting amino groups, e.g. N-(benzyloxycarbonyloxy)succinimide, to protect the amino groups at the 1-, 2'- and 6'-positions, and the resultant compound is then acylated with an acylating agent expressed by the formula R2' COOH to give the aimed compound expressed by formula I .


Inventors:
Sato, Moriyuki
Mori, Taijo
Application Number:
JP1983000143294
Publication Date:
April 25, 1984
Filing Date:
August 05, 1983
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KYOWA HAKKO KOGYO CO LTD
International Classes:
C07H15/224; A61K31/70; A61K31/7028; A61K31/7034; A61K31/7036; A61P31/04; C07H15/22; (IPC1-7): A61K31/71; C07H15/22