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Title:
NOVEL GLYCEROGLYCOLIPID COMPOUND AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5855495
Kind Code:
A
Abstract:

NEW MATERIAL:A compound shown by the formulaI(R2 is H or acetyl; AC is acetyl).

EXAMPLE: 3-0-[2-Acetamide-2-deoxy-3-0-( β-D-galactopyranosyl )-β-D-galactopyranosyl]-1,2-di-O-tetradecyl-sn-glycerol.

USE: A biochemical reagent for elucidating immune function and an antimetabolite.

PROCESS: A compound shown by the formula II is treated with phthalic anhydride, acetylated, and reacted with a compound shown by the formula III in the presence of a Lewis acid, to give a compound shown by the formula IV wherein the groups R1 and R2 are phthaloyl groups and the group R3 is acetyl group. This compound is treated with an amine, acetic anhydride, subjected to N-acetylation, treated with benzaldehyde in the presence of a Lewis acid, and reacted with a compound shown by the formula V (X is halogen) in the presence of a mercury compound. The reaction product is oxidized and hydrolyzed, deacetylated in the presence of a base under reflux, to give a compound shown by the formulaIwherein the groups R1 and R2 are H.


Inventors:
OGAWA TOMOYA
BETSUPU KAZUO
SHINNAI TADAMI
Application Number:
JP15231281A
Publication Date:
April 01, 1983
Filing Date:
September 26, 1981
Export Citation:
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Assignee:
RIKAGAKU KENKYUSHO
TEIKOKU HORMONE MFG CO LTD
International Classes:
C07H15/04; A61K31/70; A61K31/7028; A61K31/7042; A61K31/7052; A61P3/00; C07H19/04; G01N33/50; G01N33/53; (IPC1-7): C07H15/04
Attorney, Agent or Firm:
Minoru Nakamura