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Title:
NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS
Document Type and Number:
Japanese Patent JP2016034976
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide Stat3 pathway inhibitors to treat conditions.SOLUTION: The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat refractory, recurrent, or metastatic cancers; to methods of selectively killing cancer cells by using such compounds with specific administration regimens; to methods of targeting cancer stem cells by inhibiting Stat3 pathway; to methods of using novel compounds in the treatment of conditions or disorders in a mammal related to aberrant Stat3 pathway activity; and to processes for preparing such compounds and intermediates thereof, pharmaceutical compositions of the relevant compounds, and specific methods of administration of these compounds.SELECTED DRAWING: None

Inventors:
LI CHIANG JIA
JIANG ZHIWEI
HARRY ROGOFF
LI YOUZHI
LIU JIFENG
LI WEI
Application Number:
JP2015230291A
Publication Date:
March 17, 2016
Filing Date:
November 26, 2015
Export Citation:
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Assignee:
BOSTON BIOMEDICAL INC
International Classes:
A61K45/00; A61K9/10; A61K9/107; A61K9/127; A61K31/343; A61K31/665; A61K31/7088; A61K31/713; A61K47/10; A61K47/14; A61K47/24; A61K47/28; A61K47/32; A61K47/34; A61K47/38; A61K47/42; A61P1/04; A61P9/10; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P37/02; C07C45/65; C07C49/227; C07F9/655; C12N5/095; C12Q1/02; C12Q1/04
Domestic Patent References:
JP5925849B22016-05-25
Other References:
J. NAT. PROD., vol. 63, JPN6013025597, 2000, pages 492 - 495, ISSN: 0003714192
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto