Title:
NOVEL HETEROCYCLIC CARBOXYLIC ACID AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS58118565
Kind Code:
A
Abstract:
New heterocyclic carboxylic acids of the general formula (I), wherein Y<1> and Y<2> form together a removable carbonyl protecting group and R is a removable amido protecting group, are prepared in such a way that a compound of the general formula (IV), wherein Z is a C1-5 alkyl group and R is as defined above, is reacted with a compound capable for the temporary protection of the carbonyl group, the resulting compound of the general formula (III), wherein R, Z, Y<1> and Y<2> are as defined above, is treated with an alkali metal halide, and the resulting compound of the general formula (II), wherein Z, R, Y<1> and Y<2> are as defined above, is either hydrolysed selectively or separated into its isomers and the trans isomer is then hydrolysed. The resulting compounds of the general formula (I) are valuable intermediates of the synthesis of thienamycin and thienamycin analogues.
Inventors:
KARORII REMUPERUTO
GABOORU DORESUSHIYAARU
YOZUSEFU FUETSUTAA
GIYURA HORUNYATSUKU
PEETAA FUSUZUSHII
YOZUSEFU NIITORAI
GIYURA SHIMIGU
KARORII ZAUERU
CHIBOORU GIZURU
KARUMAN HARUSANII
GIYORUGII FUEKETE
RASUZURO SUZUPORUNII
GIYORUGII HAYOSU
GABOORU DORESUSHIYAARU
YOZUSEFU FUETSUTAA
GIYURA HORUNYATSUKU
PEETAA FUSUZUSHII
YOZUSEFU NIITORAI
GIYURA SHIMIGU
KARORII ZAUERU
CHIBOORU GIZURU
KARUMAN HARUSANII
GIYORUGII FUEKETE
RASUZURO SUZUPORUNII
GIYORUGII HAYOSU
Application Number:
JP23500582A
Publication Date:
July 14, 1983
Filing Date:
December 24, 1982
Export Citation:
Assignee:
RICHTER GEDEON VEGYESZET
International Classes:
C07D205/08; C07D207/28; C07D405/04; C07D411/04; (IPC1-7): C07D205/08; C07D405/04
Domestic Patent References:
| JPS56142259A | 1981-11-06 | |||
| JPS56108785A | 1981-08-28 | |||
| JPS55111463A | 1980-08-28 |
Attorney, Agent or Firm:
Asamura Akira