NEW MATERIAL:An imidazole nucleoside shown by the formula I [R1 is group shown by the formula II (one of R3 and R4 is OH, acyloxy, or acetamide, and the other is H; one of R5 and R6, and R7 and R8 is OH, acyloxy, and the other is H; one of R9 and R10 is H, CH3, CH2OH, acyloxymethyl, and the other is H), the formula III (one of R11 and R12, and R13 and R14 is OH, acyloxy, and the other is H; one of R15 and R16 is CH2OH' or acyloxymethyl, and the other is H); R2 is H, or R1].
EXAMPLE: 5-Carbamoyl-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl) imidazolium-4-olate.
USE: A water-soluble carcinostatic agent, immunosuppressive agent.
PROCESS: For example, a compound shown by the formula IV is reacted with a saccharide derivative shown by the formula V (R'3WR'8 are groups R3WR8 other than OH; R'9WR'10 are groups R9 and R10 other than CH2OH; R17 is halogen, etc.) in the presence of a condensation agent, and if necessary, deacylated, to give a compound shown by the formula I (with the proviso that R1= group shown by the formula II).
ATAMI TOSHIO
YOSHIDA NOBORU
