NOVEL INOSITOL DERIVATIVE, ITS ALUMINUM SALT, PEPTIC ULCER REMEDY COMPRISING IT, AND ITS PREPARATION

Title:

NOVEL INOSITOL DERIVATIVE, ITS ALUMINUM SALT, PEPTIC ULCER REMEDY COMPRISING IT, AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS5793942

Kind Code:

A

Abstract:

NEW MATERIAL:An inositol derivative shown by the formulaI(R is H, or lower alkanoyl) and its aluminum salt.

EXAMPLE: L-γ-Glutamylinosamine.

USE: A remedy for peptic ulcer. Low toxic, safe, having improved effect especially on chronic ulcer. Peroral medication is preferable, and its dose for adult is about 500W5,000mg/day.

PROCESS: For example, N-carbobenzoxyglutamic acid is reacted with an inosamine derivative shown by the formula II (one of R1 and R2 is NH2 and the other is OH) in an organic solvent in the presence of a condensation agent. The reaction product is hydrolyzed in the presence of acetic acid, etc., a cyclohexylidene group is removed, and hydrolyzed in the presence of a catalyst, to give a compound shown by the formulaIwherein R is H.

Inventors:

KUDOU SHIROU
AONUMA HIROMITSU
SATOU TAKAMI
KAWAMOTO AKIRA
KIMIZUKA YOSHIYUKI
MIWA MAKOTO
TAGUCHI KUNIAKI

Application Number:

JP16907080A

Publication Date:

June 11, 1982

Filing Date:

December 02, 1980

Export Citation:

Click for automatic bibliography generation Help

Assignee:

NIPPON CHEMIPHAR CO
KAWAKEN FINE CHEMICALS CO

International Classes:

A61K31/195; A61P1/04; C07C67/00; C07C231/00; C07C231/02; C07C231/12; C07C237/04; C07C237/22; (IPC1-7): A61K31/195; C07C102/00; C07C103/50

Previous Patent: 物品搬送装置

Next Patent: ANTIHYPERTENSIVE DIPEPTIDE DERIVATIVE