Title:
NOVEL KAPPA OPIOID LIGANDS
Document Type and Number:
Japanese Patent JP2020090518
Kind Code:
A
Abstract:
To provide novel ligands of Kappa (κ) opioid receptors, such as can be used to modulate a Kappa opioid receptor.SOLUTION: There is provided a compound represented by formula (I) or any pharmaceutically acceptable salt thereof, wherein the ring A can further comprise an additional nitrogen atom in any position that bears any of W, X, Y, or Z, provided that the respective group W, X, Y, or Z is absent from that position; W is H, (C1 to C6) alkyl, or the like; X is H, halo, nitro, (C1 to C6) alkyl, heteroaryl, or the like; Y is H, halo, (C1 to C6) alkyl, or the like; Z is halo, hydroxy, CN, heteroaryl, (C0 to C6) alkyl, hydroxy, (C1 to C6) alkyl, HC(=O), HC(=O), (C1 to C6)C(=O), CR(=NOR), or the like.SELECTED DRAWING: None
Inventors:
EDWARD ROBERTS
MIGUEL A GUERRERO
MARIANGELA URBANO
HUGH ROSEN
MIGUEL A GUERRERO
MARIANGELA URBANO
HUGH ROSEN
Application Number:
JP2020010476A
Publication Date:
June 11, 2020
Filing Date:
January 27, 2020
Export Citation:
Assignee:
SCRIPPS RESEARCH INST
International Classes:
C07D211/58; A61K31/44; A61K31/4439; A61K31/444; A61K31/4468; A61K31/4545; A61K31/4725; A61K31/496; A61K31/497; A61K31/498; A61K31/501; A61K31/506; A61K31/5377; A61K31/55; A61P13/02; A61P25/00; A61P25/04; A61P25/08; A61P25/18; A61P25/22; A61P25/28; A61P25/32; A61P37/02; A61P43/00; C07D213/86; C07D401/04; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D471/08; C07D487/04
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto