Title:
NOVEL LIPIDS AND COMPOSITIONS FOR DELIVERY OF THERAPEUTICS
Document Type and Number:
Japanese Patent JP2020172500
Kind Code:
A
Abstract:
To provide cationic lipids and lipid particles comprising lipids, which are advantageous for in vivo delivery of nucleic acids, as well as nucleic acid-lipid particle compositions suitable for in vivo therapeutic use, and additionally, provide methods of making these compositions, as well as methods of introducing nucleic acids into cells using these compositions, e.g., for treatment of various disease conditions.SOLUTION: The present invention provides a lipid having a structure represented by formula XXXIII or XXXVIII, or a salt or isomer thereof.SELECTED DRAWING: Figure 1
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Inventors:
MUTHIAH MANOHARAN
KALLANTHOTTATHIL G RAJEEV
MUTHUSAMY JAYARAMAN
DAVID BUTLER
NARAYANANNAIR K JAYAPRAKASH
MARTIN MAIER
LAXMAN ELTEPU
KALLANTHOTTATHIL G RAJEEV
MUTHUSAMY JAYARAMAN
DAVID BUTLER
NARAYANANNAIR K JAYAPRAKASH
MARTIN MAIER
LAXMAN ELTEPU
Application Number:
JP2020109623A
Publication Date:
October 22, 2020
Filing Date:
June 25, 2020
Export Citation:
Assignee:
TEKMIRA PHARMACEUTICALS CORP
International Classes:
C07C49/203; A61K9/14; A61K31/7088; A61K31/7105; A61K31/713; A61K39/00; A61K39/002; A61K39/02; A61K39/12; A61K45/00; A61K47/08; A61K47/16; A61K47/18; A61K47/22; A61K47/28; A61K47/54; A61K48/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P37/04; C07C31/02; C07C49/557; C07C211/21; C07C211/22; C07C237/06; C07C251/38; C07C251/78; C07C271/12; C07C271/16; C07C271/34; C07C279/12; C07C309/04; C07C321/08; C07C321/18; C07D209/48; C07D211/72; C07D213/71; C07D317/44; C12N5/10; C12N15/11; C12N15/113; C12N15/115; C12N15/117; C12N15/63; C12N15/85; C12N15/88
Domestic Patent References:
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Foreign References:
| WO2009086558A1 | 2009-07-09 | |||
| WO2010042877A1 | 2010-04-15 |
Other References:
HODOSHIMA, N. ET AL.: "Lipid nanoparticles for delivering antitumor drugs", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 146, JPN6016021196, 1997, pages 81 - 92, XP055051198, ISSN: 0004709309, DOI: 10.1016/S0378-5173(96)04779-5
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe