Title:
NOVEL LIPOPHILIC MURAMYLPEPTIDE AND ITS MANUFACTURE
Document Type and Number:
Japanese Patent JPS5649397
Kind Code:
A
Abstract:
The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.
Inventors:
RAYOSU TARUKUSEI
GERUHARUTO BASHIYANGU
ARUBERUTO HARUTOMAN
YAROSURAFU SUTANETSUKU
GERUHARUTO BASHIYANGU
ARUBERUTO HARUTOMAN
YAROSURAFU SUTANETSUKU
Application Number:
JP10233680A
Publication Date:
May 02, 1981
Filing Date:
July 25, 1980
Export Citation:
Assignee:
CIBA GEIGY AG
International Classes:
A61K38/00; A61K38/14; C07H13/00; A61K39/39; A61P37/04; C07K1/06; C07K1/113; C07K9/00; C07K14/52; C07K14/53; C07K14/535; (IPC1-7): A61K39/39; C07H15/04
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