Title:
NOVEL OXIME DERIVATIVES OF 33SUBSTITUTED 77AMINOTHIAZOLYL ACETOAMIDE CEPHALOSPORANIC ACID*THEIR MANUFACTURE AND PHARMATEUTICAL COMPOSITION CONTAINING THEM
Document Type and Number:
Japanese Patent JPS5484595
Kind Code:
A
Abstract:
Novel syn isomers of 3-substituted-7-amino-thiazolyl-acetamido-cephalosporanic acid compounds of the formula I wherein R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms and -CH2-S-R1, R1 is selected from the group consisting of 2-methyl-1,3,4-thiadiazolyl, 1-methyl tetrazolyl, acyl of an organic carboxylic acid of 2 to 4 carbon atoms and R2 is selected from the group consisting of alkyl and alkoxy of 1 to 4 carbon atoms and A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, magnesium and a non-toxic, pharmaceutically acceptable organic amine having antibiotic activity and novel intermediates and process for their preparation.
Inventors:
RUNE EEMU
ANDORE RIYUTSU
ANDORE RIYUTSU
Application Number:
JP14975778A
Publication Date:
July 05, 1979
Filing Date:
December 05, 1978
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D277/20; C07D277/40; C07D501/06; C07D501/20; C07D501/22; C07D501/24; C07D501/34; C07D501/36; C07D501/56; C07D501/59; A61K; C07D; (IPC1-7): A61K31/545; C07D501/06; C07D501/22; C07D501/36
Domestic Patent References:
| JPS51149296A | 1976-12-22 | |||
| JPS52102293A | 1977-08-27 | |||
| JPS52125190A | 1977-10-20 |