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Title:
NOVEL PEPTIDE COMPOUND AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS57114556
Kind Code:
A
Abstract:

NEW MATERIAL:The peptide compound of formulaI(R1 is n-octanoyl, stearoyl. n-docosanoyl, 2-acetoxypropionyl, etc.; R2 is H, methyl or benzyl; R3 is methoxy, carboxymethylamino, 1-methoxycarbonylethylamino, etc.; R4 is H, carboxy, methoxycarbonyl, carbazoyl, etc.; R5 is H, t-butoxycarbonyl, benzyloxycarbonyl, etc.; n is 0 or 1), or its salt.

EXAMPLE: The compound of formula II.

USE: Useful as a remedy for infectious diseases caused by pathogenic microorganisms, esp. Gram-negative bacteria, Gram-positive bacteria and fungi, and as a remedy for cancer of man and other animals.

PROCESS: The exemplified compound of formula II can be prepared, e.g. by the reaction for forming peptide bond, e.g. the reaction of the compound of formula III with the compound of formula IV. The compound of formulaIcan be prepared also by acylation reaction, methylation reaction, etc.


Inventors:
Kuroda, Yoshio
Iguchi, Hideko
Kosaka, Masanobu
Aoki, Hatsuo
Imanaka, Hiroshi
Kitaura, Yoshihiko
Nakaguchi, Osamu
Henmi, Keiji
Araya, Matsuhiko
Takeno, Shuichi
Okada, Tatsu
Tanaka, Hirokazu
Hashimoto, Shinji
Application Number:
JP1981000172658
Publication Date:
July 16, 1982
Filing Date:
October 27, 1981
Export Citation:
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Assignee:
FUJISAWA PHARMACEUT CO LTD
International Classes:
C07K1/113; A61K31/70; A61K38/00; A61P31/04; A61P35/00; C07C237/12; C07C237/22; C07H9/04; C07K5/02; (IPC1-7): A61K31/70; A61K37/02; C07C103/50; C07C103/52; C07H9/04
Domestic Patent References:
JPS5576850A1980-06-10
JPS5585552A1980-06-27
JPS5636440A1981-04-09
JPS5645447A1981-04-25



 
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