Title:
様々な腫瘍に対する免疫療法で使用される新規ペプチドおよびペプチドの組み合わせ
Document Type and Number:
Japanese Patent JP7217981
Kind Code:
B2
Abstract:
A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer, NSCLC, pancreatic cancer (PC), renal cell carcinoma (RCC), benign prostate hyperplasia (BPH), prostate cancer (PCA), ovarian cancer (OC), melanoma, breast cancer (BRCA), CLL, Merkel cell carcinoma (MCC), SCLC, Non-Hodgkin lymphoma (NHL), AML, gallbladder cancer and cholangiocarcinoma (GBC, CCC), urinary bladder cancer (UBC), and uterine cancer (UEC) includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC. A method of treating a patient who has HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC.
Inventors:
Andrea, Mare
Steebleman, rare
Weinschenk, Toni
Shall, Oliver
Fritche, jens
Shin, Harpreet
Steebleman, rare
Weinschenk, Toni
Shall, Oliver
Fritche, jens
Shin, Harpreet
Application Number:
JP2020087423A
Publication Date:
February 06, 2023
Filing Date:
May 19, 2020
Export Citation:
Assignee:
Immatics Biotechnology Gem Beher
International Classes:
C12N15/12; A61K31/7088; A61K35/12; A61K35/17; A61K35/76; A61K38/08; A61K38/10; A61K38/16; A61K39/00; A61K39/395; A61K48/00; A61P35/00; A61P35/02; C07K7/06; C07K14/725; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/0783; C12N5/10; C12N15/115; C12N15/62; C12N15/63; C12P21/02
Domestic Patent References:
| JP2003517310A | ||||
| JP2004536590A | ||||
| JP2002526110A |
Foreign References:
| WO2010037395A2 | ||||
| WO2014043441A1 |
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Shoji Akira
Takuyuki Oshima
Ayaka Nakajima
Yuriko Shinobu
Takuya Osugi
Shoji Akira
Takuyuki Oshima
Ayaka Nakajima
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