NEW MATERIAL:A compound shown by formula I [R' is H, lower alkanoyl or lower alkyl; n is 1W3; X is H or halogen; Y is -CH=CH-NHR2, etc. (R2 is formyl or lower alkanoyl)].
EXAMPLE: (2-Isonitrilvinyl)-2,5-dihydroxybenzene.
USE: A biochemical reagent, antibacterial agent or antitumor substance. Showing improved protein inhibitory activity with tyrosine specificity and inhibitory activity against multiplication of cultivated cancerous cells and antibacterial activity with a low concentration.
PREPARATION: A compound shown by formula II and isocyanomethyl phosphorous acid diethyl ester shown by formula III are subjected to well-known Wittig reaction in the presence of a base (e.g. sodium hydride), optionally hydrolyzed and further hydrogenated to give a compound shown by formula I.
TAKEUCHI TOMIO
TATSUTA KUNIAKI
ISSHIKI KUNIO
IMOTO MASAYA
JPS59175891A | 1984-10-04 | |||
JPS4945096A | 1974-04-27 | |||
JPS4857939A | 1973-08-14 | |||
JPS62238259A | 1987-10-19 | |||
JPS6168476A | 1986-04-08 |
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