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Title:
NOVEL PERFORMED CHEMICAL MEDIATOR AABUSTATIN ANALOG COMPOUND
Document Type and Number:
Japanese Patent JPS62277347
Kind Code:
A
Abstract:

NEW MATERIAL:A compound shown by formula I [R' is H, lower alkanoyl or lower alkyl; n is 1W3; X is H or halogen; Y is -CH=CH-NHR2, etc. (R2 is formyl or lower alkanoyl)].

EXAMPLE: (2-Isonitrilvinyl)-2,5-dihydroxybenzene.

USE: A biochemical reagent, antibacterial agent or antitumor substance. Showing improved protein inhibitory activity with tyrosine specificity and inhibitory activity against multiplication of cultivated cancerous cells and antibacterial activity with a low concentration.

PREPARATION: A compound shown by formula II and isocyanomethyl phosphorous acid diethyl ester shown by formula III are subjected to well-known Wittig reaction in the presence of a base (e.g. sodium hydride), optionally hydrolyzed and further hydrogenated to give a compound shown by formula I.


Inventors:
UMEZAWA HAMAO
TAKEUCHI TOMIO
TATSUTA KUNIAKI
ISSHIKI KUNIO
IMOTO MASAYA
Application Number:
JP1986000081522
Publication Date:
December 02, 1987
Filing Date:
April 08, 1986
Export Citation:
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Assignee:
MICROBIAL CHEM RES FOUND
International Classes:
C12N9/99; A61K31/165; A61K31/22; A61K31/275; A61P31/04; A61P35/00; A61P43/00; C07C67/00; C07C215/48; C07C231/00; C07C233/18; C07C241/00; C07C291/10; (IPC1-7): A61K31/165; A61K31/22; A61K31/275; C07C91/30; C07C93/14; C07C103/38; C07C119/02; C12N9/99
Domestic Patent References:
JPS59175891A1984-10-04
JPS4945096A1974-04-27
JPS4857939A1973-08-14
JPS62238259A1987-10-19
JPS6168476A1986-04-08