NEW MATERIAL:A physiologically active substance, SS33410 having following physicochemical properties: elementary analses in %, C 66.10, H 8.03; molecular weight: 790; molecular formula: C43H66O12; melting point: 131°C (decomposition); [α]D25=-21.0° [C=1% in chloroform/methanol (1:1)]; soluble in pyridine, dimethyl sulfoxide, chloroform, chloroform-methanol mixture, ethyl acetate, hard soluble in acetone, methanol, insoluble in n-hexane, ether and water; colorless column crystal which is acidic and hygroscopic; color reactions: red in vaniline- sulfuric acid, changing to dark brown by additional heating. Negative to Dragendroff's reaction.
USE: Anti-inflammatory.
PREPARATION: A strain of Streptomyces such as Streptomyces s.p-S33410 (FERM P-7679) is aerobically cultured, preferably through the submerged fermentation with agitation at 27°C for 3W7 days.
YANO KENICHI
ASAOKA TAKEMITSU
OONO JIYUNJI
OOKAWA JIYUNJI
YOKOI KOUICHI
NAKAJIMA TOSHIAKI
Next Patent: PRODUCTION OF (2S,3R)-METHYLMALIC ACID