NEW MATERIAL:A compound expressed by formula I [A and B represent (halogen-substituted) lower alkanoyloxy or link together to represent formula II and III (R1 and R2 represent H, OH or lower, alkyl, or link together with the adjacent C, to form a cyclobutane ring), etc.].
EXAMPLE: Oxalato (1,3-diamino-2-propanol) platinum (II).
USE: An antitumor agent with low toxicity.
PREPARATION: For example, potassium iodide is added to an aqueous solution of potassium chloroplatinite K2[PtCl4]. Into thus formed aqueous solution of platinous potassium iodide, is added 1,3-diamino-2-propanol to carry out the reaction and afford a compound expressed by formula IV. Then this compound is treated with silver nitrate in an aqueous solution to form a dinitrato complex expressed by formula V, which is further reacted with a desired carboxylate.
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Mogi, Kinichi
Irinoda, Kazuhiko
Kamiya, Hidehiko
Sato, Susumu
Katori, Tatsuhiko
Next Patent: NOVEL PLATIUM COMPLEX AND USE THEREOF