Title:
NOVEL PREDNISOLONE ESTER DERIVATIVE
Document Type and Number:
Japanese Patent JPS63196598
Kind Code:
A
Abstract:
NEW MATERIAL:A compound expressed by formula I (R is formula IIWIV).
EXAMPLE: (11β,17-Dihydroxy-3,20-dioxo-1,4-pregnadien-21-yl) 1-(4-chlorobenzoyl)-5- methoxy-2-methylindole-3-acetate.
USE: An anti-inflammatory agent having powerful anti-inflammatory and diuretic action as well as low toxcity and useful for treating chronic rheumatic diseases, etc., accompanied by edema.
PREPARATION: For example, prednisolone expressed by formula V is reacted with an acid chloride expressed by the formula RCOC in equimolar amounts. The above-mentioned reaction is normally carried out in the presence of a base (e.g. triethylamine, etc.) in a solvent, such as THF, etc., at room temperature for 1W24hr.
Inventors:
KOMOTO TERUO
KATORI TATSUHIKO
KATORI TATSUHIKO
Application Number:
JP2789287A
Publication Date:
August 15, 1988
Filing Date:
February 09, 1987
Export Citation:
Assignee:
SS PHARMACEUTICAL CO
International Classes:
A61K31/57; A61P29/00; C07J5/00; C07J43/00; (IPC1-7): A61K31/57; C07J5/00; C07J43/00
Attorney, Agent or Firm:
Ariga Miyuki