Title:
NOVEL PYRAZINE DERIVATIVES
Document Type and Number:
Japanese Patent JP2017171677
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a compound that is a selective agonist of Cannabinoid Receptor 2.SOLUTION: This invention relates to: a pyrazine derivative expressed by formula (I); or a pharmaceutically acceptable salt or ester thereof. The compound is used for the therapy or prophylaxis of pain, atherosclerosis, regulation of bone mass, inflammation, ischemia, reperfusion injury, systemic fibrosis, liver fibrosis, lung fibrosis, kidney fibrosis, chronic allograft nephropathy, congestive heart failure, myocardial infarction, systemic sclerosis, glomerulopathy, thermal injury, burning, hypertrophic scars, keloids, gingivitis, pyrexia, liver cirrhosis or tumors.SELECTED DRAWING: None
Inventors:
CATERINA BISSANTZ
BALEDI DHURWASULU
GRETHER UWE
ANINDYA HAZRA
PAUL HEBEISEN
STEPHAN ROEVER
MARK ROGERS-EVANS
BALEDI DHURWASULU
GRETHER UWE
ANINDYA HAZRA
PAUL HEBEISEN
STEPHAN ROEVER
MARK ROGERS-EVANS
Application Number:
JP2017102562A
Publication Date:
September 28, 2017
Filing Date:
May 24, 2017
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C07D241/24; A61K31/4965; A61K31/497; A61P1/02; A61P1/16; A61P9/04; A61P9/10; A61P11/00; A61P13/12; A61P17/02; A61P19/08; A61P25/00; A61P25/04; A61P29/00; A61P35/00; C07D401/12; C07D401/14; C07D403/04; C07D405/12; C07D405/14; C07D409/14; C07D413/12; C07D413/14; C07D417/12
Domestic Patent References:
| JP2010505788A | 2010-02-25 | |||
| JP2010505789A | 2010-02-25 | |||
| JP2008534648A | 2008-08-28 | |||
| JP2011516445A | 2011-05-26 | |||
| JP2006519833A | 2006-08-31 | |||
| JP2009541247A | 2009-11-26 |
Foreign References:
| US20050054659A1 | 2005-03-10 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni