NEW MATERIAL:A seco-prostaglandin derivative of formula I (R1 is H or 1W6C alkyl; R2 is CH3 or C2H5; Z is H or protecting group).
EXAMPLE: 6-Oxo-8-acetyl-12(S)-hydroxyheptadeca-10-trans-enoic acid methyl ester.
USE: Drug. It can be applied to the vascular vessel, kidney, digestive tracts, etc., and is effective to control inflammation, blood coagulation, blood platelet, and immune function. It can be synthesized easily, and obtained at a low cost. The activity similar to prostaglandin can be expected.
PROCESS: The compound of formula III obtained by the hydrolysis of the compound of formula II (R1' is 1W6C alkyl; Z' is protecting group) in the presence of an acidic catalyst (e.g. acetic acid, formic acid, etc.), is oxidized with chromic acid, etc., and if necessary, subjected to the elimination of the protecting group and hydrolysis to obtain the compound of formula I.
TANAKA TOSHIO
OOBA TAKEO
OKAMURA NORIAKI
SAKAUCHI KIYOSHI
WATANABE KENZOU
KUROZUMI SEIJI
OKAMIYA YOSHIAKI
NARITOMO TATSUYUKI
